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Conducting Smarter PubMed Searches

At Aptitude Health, the daily project portfolio for the Medical Publications team is extremely diverse but boils down to one thing: Effectively communicating the clinical relevance of our clients’ products. Such communication requires well-researched content that is of high quality, accurate, and up to date with the newest medical developments.

With all the available articles, and millions of additional references published each year, quickly locating relevant information can become a time-consuming and daunting task. Efficiency in scientific literature search is, therefore, an important skill that can save many frustrating hours.

In this post we share some experiences and best practices – more specifically, some simple tips and tricks that we learned over the years that may help you streamline your literature searches on one of the largest scientific online databases, PubMed.

Basic PubMed Tips and Tricks

  • Narrow your results by applying ready-to-use search filters
    Various filter options, such as article type and publication dates, are displayed to the left of your search results and can be applied by a simple click. Keep in mind: Articles that are “in process” are not yet fully PubMed indexed and lack article features used in these filters. By applying filters, you therefore risk excluding the most recent publications from your query results! Also note: Filters stay active during your search session until you change or clear them!
  • Limit your search to particular fields by using field tags
    Sometimes you may want to focus your search on articles that contain your keyword in a specific section or field in a citation, such as the title. PubMed allows you to do so by using field tags (eg, [ti] for a title word). A field tag must always follow your search term and cannot precede it. A complete list of all PubMed field tags and their descriptions can be found here
  • Locate a particular article by using the “Single Citation Matcher”
    If you don’t have the complete citation of an article, PubMed provides a simple tool, the “Single Citation Matcher,” to find your reference by entering article information by field. An auto-complete feature is available and will help you eliminate the chance of typos and other errors
  • Track down an exact phrase by putting your search term in quotation marks (“. . .”)
    Similar to other databases, PubMed allows searches with double inverted quotes for fixed-phrase searches. Keep in mind: PubMed will return search results containing only the specified words in that exact order. Therefore, erroneous spelling or inaccurate ordering of words will lead to inaccurate search outcomes!
  • Combine your search terms using Boolean logic
    The Boolean operators AND, OR, and NOT can be great time-savers by focusing your searches to fit your specific needs and demands. Including the operator AND between keywords allows you to narrow your search to articles containing each specified search term, while addition of the operator OR is used to expand your query to contain any of the terms. In contrast, NOT will exclude every citation that contains the term following this operator. Note that when you conduct a search with multiple keywords, the default operator in PubMed is AND
  • Two additional tips
    • To make even better use of Boolean operators, parentheses can be used to “nest” concepts that should be processed as a unit. For example: common cold AND (vitamin C OR zinc)
    • The “History” tab featured under the “Advanced” settings displays your searches in the actual order they were run (#1, #2, etc). From this page, it is possible to combine previous searches into new and more complex search strategies using Boolean operators. For example: (#1 OR #2) AND cancer

Using the above tips, an infinite range of search strategies and queries can be created. However, keep in mind that less can be more! Adding different techniques sequentially may be more productive than combining them all at once.

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Matthew Gordon

VP, Real-World Evidence
Matthew has more than 25 years of experience in real-world evidence and observational, non-interventional research. He has led studies across the full life cycle—from startup through publication—supporting objectives that range from understanding a disease’s natural history to fulfilling global safety surveillance requirements. Matthew brings deep expertise in orphan disease programs, having overseen more than 25 long-term, global initiatives, as well as in disease and product registries, prospective pharmacoeconomic studies, and systematic literature reviews. Matthew leads the RWE Registries team, responsible for building the business and team. Prior to joining Aptitude Health, he held senior leadership roles at Parexel, Worldwide Clinical Trials, inVentiv Health Clinical, Quintiles Outcome, and ICON Clinical Research. Matthew holds a BA in sociology from Boston University, is a long-standing member of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR), and is a frequent speaker at ISPOR, the Center for Business Intelligence, and related industry conferences.

Gerald Stanvitch, PhD

VP, Scientific Content

Cate Browning, PhD

VP, Global Medical Affairs

Erin Zingales Rau

VP, Account Services

Kelly Kocor

VP, People & Culture
Kelly leads both the human resources and talent acquisition teams, ensuring that Aptitude Health attracts, retains, and develops top personnel to drive our continued success. With over 17 years of experience transforming global HR initiatives, Kelly is an expert in harmonizing HR policies and fostering a culture of engagement and partnership. She is committed to partnering with all areas of the business to ensure full regulatory compliance and delivering value-added services to our organization and its people. Kelly is passionate about developing and implementing HR strategies that help support our employees’ professional and personal growth. She is dedicated to fostering a culture that encourages innovation, collaboration, and inclusivity, helping Aptitude Health continue to be a great place to work.

Bart Zygmond

VP, Finance
Bart brings a wealth of experience to the organization, having worked in the life sciences, pharmaceuticals, manufacturing, and service industries. With his expertise in financial reporting, US GAAP, SOX, cash flow modeling, and financial analysis, he plays a crucial role in the company’s financial management and strategy. Prior to joining Aptitude Health as VP, Finance, Bart held several controller positions: at Q2 Solutions, he oversaw the global finance team and financial operations, ensuring the accurate and timely financial reporting of the company. He also held controller positions at Domtar Inc and Veristat.

Eugene Vissers, MD

Senior VP, Global Scientific Content
Eugene is a seasoned medical doctor with over 20 years of international experience in pharma, consultancy, and agency environments. Eugene leads the US team of dedicated experts responsible for developing high-quality medical content. Prior to joining Aptitude Health, Eugene served as medical director at Ipsen and AstraZeneca. With both his medical degree and an MBA, Eugene brings a unique perspective to his role. His clinical background, combined with his business acumen, allows him to develop innovative strategies that drive results. Under Eugene’s leadership, the medical content team delivers scientific information of the highest quality, providing valuable insights to our clients around the world.

Adrian Barfield

VP, US Business Development

Kelley Hernandez

Executive VP, US Business Development
Kelley has over 18 years of experience in the oncology space. Kelley joined Aptitude Health after working with Cardinal Health, where she was part of the Healthcare and Analytics Division, and finished her tenure there with VitalSource™ (GPO division). As the leader of the strategic business development team for the US, Kelley brings a wealth of expertise to the organization. Her experience in the healthcare industry, combined with her ability to identify and capitalize on new business opportunities, is invaluable in driving the company’s growth and success. Kelley’s dedication to building strong relationships with life science partners is a testament to her commitment to delivering exceptional value to the healthcare industry.

Adam Sinensky, MBA

Chief Technology Officer

Adam has over 20 years of experience in the healthcare industry and an MBA in healthcare management. After 10 years as a strategy consultant to life science companies, Adam has spent the last decade as a product and strategy leader focused on bringing technology products to market across the payor, provider, and life sciences segments. By combining his business acumen and experience working directly with software developers, engineers, and data scientists, Adam has successfully led numerous product launches and enhancements from ideation to development and go-to-market initiatives. His product and change management expertise has led organizational shifts from services to technology at companies such as Change Healthcare and Datavant/Ciox. At Aptitude Health, Adam is responsible for growing our portfolio of product offerings by leveraging real-world data and artificial intelligence with our existing solutions and industry-leading Axess Network of healthcare providers. He also oversees our IT and cybersecurity teams.

Stefanie Daniels

Chief Commercial Officer

Stefanie is a seasoned healthcare executive with over 20 years of experience in oncology. She brings a wealth of knowledge and expertise to the organization. Stefanie joined Aptitude Health after spending over a decade as a senior director at Physicians’ Education Resource, an oncology CME vendor. During her tenure, she led and managed teams responsible for grant development/acquisition, program creation/execution, and faculty management. Stefanie’s deep understanding of the oncology industry and her ability to lead teams through complex projects make her a vital part of the organization’s success. Her dedication to providing high-quality solutions to our life science partners is a testament to her commitment to improving cancer patient care.

Jason Cash

Chief Financial Officer

Jason is an accomplished finance professional with over 20 years of experience in the pharmaceutical services industry. Throughout his career, he has demonstrated a keen ability to navigate high-growth organizations, delivering exceptional results. Before joining Aptitude Health, Jason served as the CFO of Veristat International, a global contract research organization. In this role, he led the financial strategy and played a pivotal role in driving the company’s growth and success. Jason’s wealth of experience and expertise in financial management make him an essential member of the leadership team. His strategic thinking and ability to drive results are highly respected within the industry.

Jez Moulding

Chief Executive Officer
Jez is a seasoned leader with over 20 years of experience in general management and regional president roles. He has a proven track record of success in the healthcare industry, having worked in the US, Japan, Australia, Korea, South Africa, France, and the UK for Sanofi, where he supported the launch of 10 new drugs across various therapeutic areas. As chief commercial officer at UDG Healthcare and EVP at Ashfield, Jez demonstrated his expertise in developing and implementing successful business strategies. He joined Aptitude Health from Pharmaspectra, an IQVIA business, where he served as CEO since 2018. Jez’s extensive experience in the pharmaceutical industry and his leadership skills make him an invaluable asset to the organization.