Insights Into HER2+ Breast Cancer

Perspectives on current treatment practices regarding HER2+ metastatic breast cancer, management of progressive HER2+ metastatic disease, and attitudes toward recently introduced and upcoming agents.

October 14, 2020

Faculty Chair

Joyce A. O’Shaughnessy, MD

Texas Oncology-Baylor Charles A. Sammons Cancer Center, TX, US

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Initial Treatment of HER2-Positive Advanced Breast Cancer

  • Overview of current data
    • Initial therapy
      • Impact of prior adjuvant therapy, disease-free interval, disease and patient characteristics
      • Is dual HER2 blockade the standard?
      • Which HER2-targeted agents?
      • Which chemotherapy partner?

Management of Progressive HER2-Positive Metastatic Disease

  • Overview of current data
    • Treatment of progressive disease
      • Newer agents (approved and in development)
        • Trastuzumab deruxtecan
        • T-DM1
        • Tucatinib
        • Neratinib
      • Management of emerging safety issues with HER2-directed therapies (pneumonitis, diarrhea, and interstitial lung disease)
      • Evolving guidelines for monitoring brain metastases


  • A moderated virtual roundtable discussion focusing on treatment of metastatic breast cancer was held October 14, 2020
  • The group of advisors comprised 9 community oncologists
  • Data collection was accomplished through use of audience response system questioning and moderated discussion

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