CASES Insights Into Breast Cancer Central 2020

Perspectives on current treatment practices in the central region of the US regarding therapy of HR+, HER2+, and triple-negative advanced breast cancer. And insights on current treatment practice attitudes toward recently introduced and upcoming agents

Central – May 2, 2020

Faculty Chair

Mark Pegram, MD

Stanford Women’s Cancer Center, Palo Alto, CA, USA

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Insights on the following breast cancer therapies were obtained

  • HR+: fulvestrant, letrozole, AIs, CDK4/6 inhibitors, PI3K and mTOR inhibitors, HDAC inhibitors, chemotherapies
  • HER2+: trastuzumab (and potential biosimilars), lapatinib, pertuzumab, T-DM1, neratinib, AIs, mTOR inhibitors, chemotherapies
  • TNBC: PARP inhibitors, pembrolizumab, enzalutamide, antibody-drug conjugates (sacituzumab govitecan, GPNMB), immunotherapy, chemotherapies


  • A moderated virtual roundtable discussion focusing on treatment of metastatic breast cancer was held in May 2020
  • Disease state and data presentations were developed in conjunction with Mark Pegram, MD, a medical expert from Stanford Women’s Cancer Center
  • The group of advisors comprised 13 community oncologists from the central region of the USA
  • Data collection was accomplished through use of audience response system questioning and moderated discussion

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